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2014年5月21日 星期三

餵藥神器?


2014年5月20日 星期二

肝腎功能不好 用藥調整

許多藥物,碰到肝腎功能不好的病人,劑量可能需要調整.

仿單上可能會註明:
2.5 Adults with Hepatic or Renal Impairment In adult patients with liver or renal impairment, a starting dose of one 5-mg tablet every other day is recommended based on pharmacokinetic data.

仔細找找原廠的仿單,後面有提到該要針對肝腎功能不全的患者,所作的臨床試驗結果.
總試驗人數內.什麼樣的肝腎功能不全佔多少人,如何影響藥物的代謝.

Renally Impaired: Desloratadine pharmacokinetics following a single dose of 7.5 mg were characterized in patients with mild(n=7; creatinine clearance 51–69 mL/min/1.73 m2), moderate (n=6; creatinine clearance 34–43 mL/min/1.73 m2), and severe (n=6;creatinine clearance 5–29 mL/min/1.73 m2) renal impairment or hemodialysis dependent (n=6) patients. In patients with mild and moderate renal impairment, median Cmax and AUC values increased by approximately 1.2- and 1.9-fold, respectively, relativeto subjects with normal renal function. In patients with severe renal impairment or who were hemodialysis dependent, Cmax and AUC values increased by approximately 1.7- and 2.5-fold, respectively. Minimal changes in 3-hydroxydesloratadine concentrations were observed. Desloratadine and 3-hydroxydesloratadine were poorly removed by emodialysis. Plasma protein binding of desloratadine and 3-hydroxydesloratadine was unaltered by renal impairment. Dosage adjustment for patients with renal impairment is recommended.

Hepatically Impaired: Desloratadine pharmacokinetics were characterized following a single oral dose in patients with mild (n=4), moderate (n=4), and severe (n=4) hepatic impairment as defined by the Child-Pugh classification of hepatic function and 8 subjects with normal hepatic function. Patients with hepatic impairment, regardless of severity, had approximately a 2.4-fold increase in AUC as compared with normal subjects. The apparent oral clearance of desloratadine in patients with mild, moderate, and severe
hepatic impairment was 37%, 36%, and 28% of that in normal subjects, respectively. An increase in the mean elimination half-life of desloratadine in patients with hepatic impairment was observed. For 3-hydroxydesloratadine, the mean Cmax and AUC values for patients with hepatic impairment were no statistically significantly different from subjects with normal hepatic function. Dosage adjustment for patients with hepatic impairment is recommended [see Dosage and Administration (2.5)].

不過坦白說,也不是所有的都寫得很清楚,大部分就只提到肝腎功能不全的患者,劑量要做調整.
但是肝腎功能不全的臨床指標及判別,還是由醫師做判斷.當然各院的標準可能不一.

我雖然想給正確的臨床判別數字,但真的沒有啊!!!


腎功能不全病人的藥物劑量調整-三總藥訊



2014年5月2日 星期五

iPhone 5 vs 小米3 照相比較

八百萬相素vs一千多萬相素
看起來都還不錯!
你猜的出來是那一台拍的嗎?

放大細節呢?

細節上,
相素較高的反而沒有特別的優勢!